Would you like to request Knight ADRC resources? Please review our Policies & Procedures before you begin your request. Failure to review documents at that link may result in your request being delayed.
A major goal of the Knight ADRC is to foster, facilitate and support research on dementia and aging. To this end, the Center recruits research participants to participate in longitudinal cognitive, neuropsychologic, imaging, and biomarker assessments. The data (including clinical and cognitive measures, MRI and amyloid imaging scans) and tissue samples (autopsied brain tissue, plasma, and cerebrospinal fluid) are available to qualified investigators after appropriate review. Eligible participants may also be invited to enroll in the research of other investigators after appropriate review. Investigators can request access to these resources by submitting a resource request via this website.
As with any mature (30+years), longitudinal study, our data is complex: tests and procedures have been added and dropped, enrollment criteria have changed, studies have started and ended (Parkinson’s disease, very old, Lewy body disease, stroke, etc.), and funding levels have varied. Although we have data on over 3600 research participants, the sample size for a particular request will dwindle quickly depending on eligibility criteria and measures requested. For example amyloid imaging was initiated in 2004; through August 31, 2010, 449 participants have undergone this assessment. Of these 449 participants, 161 are enrolled in a younger cohort that receives a different set of neuropsychologic tests that would not be comparable to tests for the older cohort. If other criteria are added, the sample size reduces quickly (e.g. if APOE4-positive participants with amyloid imaging are required, only 100 potential participants remain eligible). If e4 homozygous participants are specified, then only 15 would remain eligible. Additional diagnostic restrictions can also limit potential participants. Comorbidities in an elderly sample are very common; requests for ‘pure’ Alzheimer’s disease with no depression, cerebrovascular disease, etc. are very difficult to fulfill.
Recommendations: It is important that the investigator communicate all eligibility criteria and variables of interest when applying. If the science can be flexible, choose the least restrictive criteria. The application should initiate a dialog between the investigator and the Center to further refine the request.